This study used fMRI to investigate the neural substrates of moral cognition in health resource allocation decision problems. In particular, it investigated the cognitive and emotional processes that underpin utilitarian approaches to health care rationing such as Quality Adjusted Life Years. Participants viewed hypothetical medical and nonmedical resource allocation scenarios which described equal or unequal allocation of resources to different groups. In addition, participants were assigned to 1 of 2 treatments in which they either did or did not receive advanced (...) instructions about the principles of utilitarianism. In all cases, participants were asked to judged the proposed allocations as “fair” or “unfair.” More brain activity was observed within the superior parietal lobe, angular gyrus, middle temporal gyrus, and bilateral caudate nucleus when participants viewed scenarios depicting equal divisions of resources. Conversely, unequal resource divisions were associated with more activity in the inferior frontal gyrus and insula cortex. Furthermore, instructions about the principles of utilitarianism led to significant activation differences within the inferior frontal gyrus and the middle frontal gyrus. Significant differences in activity were also found within the inferior frontal cortex and anterior insula between medical and nonmedical scenarios. The implications for cognitive control mechanisms and the cognitive and neural bases of utilitarian ethical judgment are discussed. (shrink)

Volume 20, Issue 7, July 2020, Page 77-80.

Preparing the Next Generation of Oral Historians is an invaluable resource to educators seeking to bring history alive for students at all levels. Filled with insightful reflections on teaching oral history, it offers practical suggestions for educators seeking to create curricula, engage students, gather community support, and meet educational standards. By the close of the book, readers will be able to successfully incorporate oral history projects in their own classrooms.

The proliferation of personal data collection practices fundamentally reshapes how society is ordered and commercialized, and demands reconsideration of the possibilities for a just and equitable s...

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

This paper extends the sensibilities of the Gilligan-Kohlberg debate into classical political economy and makes links with modern psychotherapeutics and the psychological development of individuals. The model of moral maturity represented in contemporary psychological theories is posited as the direct descendant, not only of Immanuel Kant, as is generally argued, but also of the universal, homogenous agent of classical economics; the ‘rational economic man’ representedin the writings of Adam Smith and J. S. Mill. Both thinkers lent their support to (...) the creation of an order which produces (masculine) actors who are ’rational’ self-governing, separative, competitive, self-asserting, self-interested, acquisitive, pecuniary and driven to success by a desire for the social recognition afforded by consumerism; the same order which typically designates women moral failures and which renders them largely invisible. Liberalism generates conditions which enable it to sustain and reproduce itself at the psychic level. The assumption of the market as the paradigmatic social interaction and its status as the analytical and moral starting point in liberal capitalism infects the putatively private domain of ‘self-governance’ and contemporary psychotherapeutics; the development and management of the self in contemporary culture is a direct reflection of the imperatives and assumptions of market society. The separative self is the ‘healthy’ self, hence the parallel emphasis in modern therapy on ‘individuation’ as the highest level of psychological evolvement. Gilligan’s ‘care ethic’ is approached with some scepticism, nevertheless, her critique of Kohlberg guides us towards a more comprehensive critique of the ‘pneumatic’ and political assumptions of liberalism. (shrink)

Historians and cultural critics face special challenges when treating the nonhuman natural world in the medieval and early modern periods. Their most daunting problem is that in both the visual and written records of the time, nature seems to be both everywhere and nowhere. In the broadest sense, nature was everywhere, for it was vital to human survival. Agriculture, animal husbandry, medicine, and the patterns of human settlement all have their basis in natural settings. Humans also marked personal, community, and (...) seasonal events by natural occurrences and built their cultural explanations around the workings of nature, which formed the unspoken backdrop for every historical event and document of the time. Yet in spite of the ubiquity of nature's continual presence in the physical surroundings and the artistic and literary cultures of these periods, overt discussion of nature is often hard to find. Until the sixteenth century, responses to nature were quite often recorded only in the course of investigating other subjects. In a very real sense, nature went without saying. As a result, modern scholars analyzing the concept of nature in the history of medieval and early modern Europe must often work in deeply interdisciplinary ways. This challenge is deftly handled by the contributors to Engaging with Nature, whose essays provide insights into such topics as concepts of animal/human relationships; environmental and ecological history; medieval hunting; early modern collections of natural objects; the relationship of religion and nature; the rise of science; and the artistic representations of exotic plants and animals produced by Europeans encountering the New World. "As scholars of medieval and early modern Europe increasingly embrace environmental perspectives and animal studies, Engaging with Nature will be recognized as a landmark collection in the field. Taken together, the essays in this volume provide a synthetic overview of critical developments in the many disciplines that are now incorporating the approaches of natural and environmental studies. Each essay represents a substantial advance in scholarship and thought in its particular field. This is an essential collection for literary and cultural historians, and for historians of economy and society, art and ideas." --Rita Copeland, University of Pennsylvania "Engaging with Nature vividly captures the breadth and depth of human interactions with the natural world in premodern Europe. Its multidisciplinary approach generates new questions about how Europeans understood and connected with nature and delves into issues that will interest the specialist and the general reader alike. The book challenges readers to rethink not just the history of human engagement with nature but also the many ways the past has influenced our modern conceptions of ecology and environment." --James Masschaele, Rutgers University "This substantial collection of articles is far more than a response to current obsessions with climate change. It is a thought-provoking demonstration of the inter-disciplinary character of research on medieval history and culture. Students of medieval and early-modern society and economy, literature, philosophy, and art, will find much that is new in these essays, and much to provoke their own thinking about the vexed relationship of human societies with their natural surroundings." --Fredric Cheyette, Emeritus professor of history, Amherst College "Engaging with Nature is a deeply pleasurable volume to read. Using an incredible range of primary and secondary sources, the authors richly realize the methodological promise inherent in the emergent field of medieval and pre-modern studies on the history of nature." --Kathleen Biddick, Temple University "Engaging with Nature is a collection of impeccable scholarship that will make a highly original contribution to the emergent field of medieval and pre-modern studies on the history of nature." --Claire Sponsler, University of Iowa. (shrink)

My assumption is that thought itself arises out of incidents of living experience and must remain bound to them as the only guideposts by which to take its bearings. Hannah Arendt.

I explore Locke’s complex attitude toward the natural philosophy of his day by focusing on Locke’s own treatment of Newton’s theory of gravity and the presence of Lockean themes in defenses of Newtonian attraction/gravity by Maupertuis and other early Newtonians. In doing so, I highlight the inadequacy of an unqualified labeling of Locke as “mechanist” or “Newtonian.”.

I. Introduction Siris, Berkeley's last major work, is undeniably a rather odd book. It could hardly be otherwise, given Berkeley's aims in writing it, which are three-fold: 'to communicate to the public the salutary virtues of tar-water,'1 to provide scientific background supporting the efficacy of tar-water as a medicine, and to lead the mind of the reader, via gradual steps, toward contemplation of God.2 The latter two aims shape Berkeley's extensive use of contemporary natural science in Siris. In particular, Berkeley's (...) focus on what he calls fire (or aether or light) as a quasiuniversal 'cause' of natural change3 serves these purposes, for the 'activity' of the aether, in his view, can both explain the miraculous virtues of a certain medicine, i.e. tar-water, and reveal God's action and his divine order.4 Berkeley's corpuscular speculations, including his use of fire-theory, are not especially idiosyncratic as natural philosophy. In his theorizing, as Jessop and other have noted, he is heavily indebted to the work of Hermann Boerhaave, the Dutch chemist, botanist, and physician whose teachings were highly influential in mid-eighteenth century Britain.5 Boerhaave, along with other Dutch natural philosophers cited by Berkeley, assigned a central role in accounting for physio-chemical activity to fire, a subtle, insensible particulate substance, sometimes identified with light. (shrink)

In this paper, I discuss the work of W. E. B. Du Bois to expose the disastrous effects of white supremacy in the U.S. and the world. While his early works suggest that white supremacy might be rehabilitated by the careful presentation of contrary evidence, in later works he catalogs the primary features of whiteness, including an infantile comportment, a pathological attachment to innocence, and an epistemic incapacity to absorb evidence of its own error. To capture the scope of the (...) delusion of whiteness on Du Bois’s account, I suggest the term “irrevocable license.” The remainder of the paper uses Du Bois’s account to examine the case of a “Karen”—a white woman who obliviously and inappropriately interferes with the lawful actions of a family of color—and further considers police violence against people of color as an outgrowth of white irrevocable license. (shrink)

The Cambridge Companion to Locke now joins the long list of titles available in this excellent series. As we have come to expect, the contributors to this Companion are distinguished and the result is comprehensive and eminently useful. This volume is one of the more accessible in the series, with most of the chapters pitched at a level accessible to advanced undergraduates and especially helpful to beginning graduate students. Many of the chapters will be of considerable interest to scholars; here (...) I myself think especially of Edwin McCann’s chapter on Locke’s philosophy of body, which considerably advances our understanding of the place of mechanism in Locke’s thought. In addition, the notes, selective bibliography, and index of passages cited will serve as resources for readers at all levels of expertise. (shrink)

In their paper "Conceptual Challenges in the Neuroimaging of Psychiatric Disorders," Kanaan and McGuire (2011) review a number of methodological and analytical obstacles associated with the use of functional magnetic resonance imaging (fMRI) to study psychiatric disorders. Although we agree that there are challenges and limitations to this end, it would be a shame for those without a background in neuroimaging to walk away from this article with the impression that such work is too daunting, and thus not worth pursuing. (...) On the contrary, despite a number of challenges (which are an inevitable part of all research), fMRI has already contributed many important insights into the nature and mechanisms of .. (shrink)

Ageing causes progressive decline in metabolic, behavioural, and physiological functions, leading to a reduced health span. The extracellular matrix (ECM) is the three‐dimensional network of macromolecules that provides our tissues with structure and biomechanical resilience. Imbalance between damage and repair/regeneration causes the ECM to undergo structural deterioration with age, contributing to age‐associated pathology. The ECM ‘Ageing Across the Life Course’ interdisciplinary research network (ECMage) was established to bring together researchers in the United Kingdom, and internationally, working on the emerging field (...) of ECM ageing. Here we report on a consultation at a joint meeting of ECMage and the Medical Research Council / Versus Arthritis Centre for Integrated Research into Musculoskeletal Ageing, held in January 2023, in which delegates analysed the key questions and research opportunities in the field of ECM ageing. We examine fundamental biological questions, enabling technologies, systems of study and emerging in vitro and in silico models, alongside consideration of the broader challenges facing the field. (shrink)

This is a book symposium on Steffen Borge’s The Philosophy of Football. It has contributions from William Morgan, Murray Smith and Brian Weatherson with replies from Borge.

The purpose of this qualitative study was to examine the perceptions related to ethics and cheating among a representative sample of primarily female undergraduate students, compared to trends reported in the literature. Focus groups were organized to discuss nine scripted questions. Transcripts and audiotapes were analyzed and four main themes emerged: demographics of those who cheat, students’ perceptions of cheating, the role of technology in cheating, and consequences of cheating, including students’ attitudes and behaviors related to reporting cheating incidents. Bandura’s (...) Social Cognitive Theory served as the theoretical framework to understand students’ varying perceptions of and justification for cheating, as well as the dynamics of honor code violations, via group discussion. Viewpoints on cheating were regularly discussed and contradictory views were identified related to frequency and justification for cheating. Utilizing the constant comparative method, students mentioned time limitations, and pressure from peers, parents, and professors as reasons to cheat. They also discussed pressures to achieve high grades for acceptance into graduate programs. Students were also reluctant to report their classmates for cheating incidents. Repeated and comprehensive education on ethical behavior is warranted. (shrink)

Stem cell science is advancing at an unprecedented rate, with thousands of research papers being published every year and many clinical trials for a wide range of conditions underway as registered on ClinicalTrials.gov. This rapidly expanding and alluring field has brought with it ever more complex and multifaceted ethical issues, many of which require new guidelines, consent protocols and even change in legislation, since they do not fit comfortably in the existing bioethical regulations and protocols. Keeping up with the ethical (...) implications of stem cell research is daunting to the expert and non-expert. We review the various types of stem cells and then focus on multipotent and pluripotent cell types, since it is these cell types that bring with them the greatest research and therapeutic potential, while concurrently delivering novel ethical conundrums. Certain key considerations are currently lacking and what is needed is how to obtain permission from individuals who donate their biological material for both scientific inquiry and eventually, for their potential therapeutic utility. (shrink)

The most common solutions to the problem of high pharmaceutical prices have taken the form of regulations, price negotiations, or changes in drug coverage by insurers. These measures for the most part transfer the burden of drug expenditures between pharmaceutical companies and payers or between payers. The aim of this study is to propose an alternative model for the relationship between the main stakeholders involved in the price setting and purchasing of pharmaceuticals, one that encourages a more cooperative approach. We (...) draw from principles of ethics and health economics and apply them to the context of the pharmaceutical industry. The model prioritises two objectives, to make drugs financially accessible to the patients who need them, and to keep pharmaceutical companies viable and profitable. It is centered around the sharing of financial risk between the main stakeholders, which we describe as ‘enlightened risk sharing’. After establishing the foundations of this model, we expand on the type of policies that can follow these principles with current day examples. (shrink)

This study invited curates and training incumbents attending a 3-day residential programme to function as a hermeneutical community engaging conversation between the Lucan post-resurrection narrative concerning the Road to Emmaus and the learning relationship in which they were engaged. Building on the SIFT approach to biblical hermeneutics the participants were invited to work in type-alike groups, structured first on the basis of the perceiving process and second on the basis of the judging process. This approach facilitated rich and varied insights (...) into the Emmaus Road narrative and into the theme of learning relationships. (shrink)

This qualitative study was positioned within an emerging scientific field concerned with the interaction between biblical text and the psychological profile of the preacher. The theoretical framework was provided by the sensing, intuition, feeling and thinking approach to biblical hermeneutics, an approach rooted in reader-perspective hermeneutical theory and in Jungian psychological type theory that explores the distinctive readings of sensing perception and intuitive perception, and the distinctive readings of thinking evaluation and feeling evaluation. The empirical methodology was provided by developing (...) a research tradition concerned with applying the SIFT approach to biblical text. In the present study, a group of 17 Anglican clergy were invited to work in psychological type-alike groups to explore two of the biblical passages identified by Year B of the Revised Common Lectionary for the Feast of Christ the King. Dividing into three workshops, according to their preferences for sensing and intuition, the clergy explored Psalm 93. Dividing into three workshops, according to their preferences for thinking and feeling, the clergy explored John 18:33–37. The rich data gathered from these workshops supported the hypothesis that biblical interpretation and preaching may be shaped by the reader’s psychological type preference and suggested that the passages of scripture proposed for the Feast of Christ the King may be a joy for intuitive thinking types, but a nightmare for sensing feeling types.Contribution: Situated within the reader perspective approach to biblical hermeneutics, the SIFT method is concerned with identifying the influence of the psychological type of the reader in shaping the interpretation of text. Employing this method, the present study contributes to the fields of homiletics and hermeneutics by demonstrating how some readers may struggle more than others to interpret the scripture readings proposed by the lectionary for the Feast of Christ the King. (shrink)

This study explores the connection between dominant psychological type preferences and reader interpretations of biblical texts. Working in type-alike groups, a group of 40 Anglican clergy were invited to employ their strongest function to engage conversation between Mark’s account of Jesus sending out the disciples and the experience of ministry in today’s world. The data supported the hermeneutical theory proposed by the SIFT approach to biblical interpretation and liturgical preaching by demonstrating the four clear and distinctive voices of sensing, intuition, (...) feeling and thinking. (shrink)